Ya-weng Tseng, Joern Diedrichsen, John Krakauer, Reza Shadmehr, and Amy Bastian (2007) Sensory prediction errors drive cerebellum-dependent adaptation of reaching. Journal of Neurophysiology, in press.

Abstract The cerebellum is an essential part of the neural network involved in adapting goal-directed arm movements. This adaptation might rely on two distinct signals: a sensory prediction error, or a motor correction. Sensory prediction errors occur when an initial motor command is generated but the predicted sensory consequences do not match the observed values. In some tasks, these sensory errors are monitored and result in online corrective motor output as the movement progresses. Here we asked whether cerebellum-dependent adaptation of reaching relies on sensory or online motor corrections. Healthy controls and people with hereditary cerebellar ataxia reached during a visuomotor perturbation in two conditions: “shooting” movements without online corrections, and “pointing” movements that allowed for online corrections. Sensory (i.e. visual) errors were available in both conditions. Results showed that the addition of motor corrections did not influence adaptation in control subjects, suggesting that only sensory errors were needed for learning. Cerebellar subjects were comparably impaired in both adaptation conditions relative to controls, despite abnormal and inconsistent online motor correction. Specifically, poor online motor corrections were unrelated to cerebellar subjects’ adaptation deficit (i.e. adaptation did not worsen), further suggesting that only sensory prediction errors influence this process. Therefore, adaptation to visuomotor perturbations depends on the cerebellum, and is driven by the mismatch between predicted and actual sensory outcome of motor commands.

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